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@Denis (with one n)Fools! It is an umbrella of course.

As in there is a monster in your parsimony...
?si=X_BegG_X751je61I

@Looney LesI think it is a fish.

@Woozy in WollongongWhats that mate? Some German opera?

We are alone and our maladies are parsimony.

@Dr KnowitallDespite increasing evidence Covid related T cell depletion denialism is now a thing in the scientific community.

@Dr KnowitallOk checked out Dr Robert's (do people still pay money to see themself with you?) references. Many of thesm are commentary pieces rather than research. And very little direct evidence of permanent T cell depletion in COVID is presented. Which is completely different with HIV, where the virus targets the CD4 T cell and kills it.

But that doesn't mean COVID has no effect on immune system. It does, but to varying degrees for different people. And it is possible that there will be downstream debilitating effects on the immune system from it. But it is definitely not as much as in AIDS.

And with that no further correspondence will be entered into.

It's only long covid until you die.

Ok, long COVID different. Let me enlighten you later... Saving lives here!

T cell depletion was suspected early on in the pandemic. This first paper from 2019
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30183-5/fulltext

COVID is a lympho-manipulative pathogen which creates a dysfunctional immune response:
https://www.frontiersin.org/articles/10.3389/fimmu.2020.600405/full

"Covid-19?s ability to interfere with how T cells recognize their viral particles is the reason why T cell responses fail and do not make the grade."
https://www.tandfonline.com/doi/full/10.1080/14760584.2022.20771960

"A research team that has autopsied people who died from COVID-19 has now discovered they lack so-called germinal centers, classrooms in the spleen and lymph nodes in which immune cells learn to mount a long-lasting antibody response to a pathogen."
https://www.science.org/content/article/coronavirus-may-shut-down-immune-system-s-vital-classrooms

Sustained cellular immune dysregulation in individuals recovering from SARS-CoV-2 infection
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773371/

A substantial proportion of patients who have recovered from coronavirus disease-2019 (COVID-19) experience COVID-19–related symptoms even months after hospital discharge. We extensively immunologically characterized patients who recovered from COVID-19. In these patients, T cells were exhausted, with increased PD-1+ T cells, as compared with healthy controls.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8783674/

Persistence of SARS-CoV-2 and Long COVID - A spectrum of immune dysregulation
https://www.doherty.edu.au/news-events/setting-it-straight/issue-118-persistence-of-sarscov2-long-covid-spectrum-immune-dysregulation

We demonstrate that viral antigen-positive T cells from patient undergone pronounced apoptosis. In vitro infection of T cells induced cell death that is likely in mitochondria ROS-HIF-1a-dependent pathways.
https://www.nature.com/articles/s41392-022-00919-x

SARS COV-2 INFECTS T LYMPHOCYTES CAUSING THEIR EXHAUSTION AND APOPTOSIS CONTRIBUTING TO IMMUNE DYSFUNCTION AND LYMPHOPENIA THAT FAVORS VIRAL PERSISTENCE
https://www.researchgate.net/publication/359330070_SARS_COV-2_INFECTS_T_LYMPHOCYTES_CAUSING_THEIR_EXHAUSTION_AND_APOPTOSIS_CONTRIBUTING_TO_IMMUNE_DYSFUNCTION_AND_LYMPHOPENIA_THAT_FAVORS_VIRAL_PERSISTENCE

A recent study of 99 patients with long COVID found exhausted T cells that suggested the patients were fighting an active chronic infection. The strength of T-cell exhaustion also corresponded with the reactivation of Epstein-Barr virus in patients.
https://www.medrxiv.org/content/10.1101/2022.08.09.22278592v1.full.pdf

Acquired lymphocytopenia can occur with a number of other disorders The most common causes include
Protein-energy undernutrition
HIV infection
COVID-19
https://www.msdmanuals.com/professional/hematology-and-oncology/leukopenias/lymphocytopenia

Global patterns of antigen receptor repertoire disruption across adaptive immune compartments in COVID-19
https://www.pnas.org/doi/10.1073/pnas.2201541119

Microbiologist Brendan Crabb, director of Melbourne’s Burnet Institute told Bloomberg that he’d be surprised if COVID didn’t have an effect on the infectiousness of other diseases given its documented impairment of the immune system in long COVID patients. "You’ve got the best part of 100 million to half a billion people in the world who are very changed in their capacity to respond to viruses,” Crabb told Bloomberg. “There’s no way that can mean business as normal for microbial ecology.”
https://www.bloomberg.com/news/newsletters/2022-09-05/kids-with-liver-damage-polio-monkeypox-tomato-flu-viruses-are-behaving-badly


The risk of cardiovascular disease, for example, increased after one infection, but doubled in people who had two infections, and tripled in those who had been infected thrice. The numbers translate into 50 extra cases of heart disease per 1,000 people who've had COVID-19 twice
https://www.abc.net.au/news/health/2022-07-29/covid-19-three-myths-challenge-lies-ahead/101274980

Show us where is the evidence of depletion of T Cells after COVID? Havent seen any...

Depression is misanthropic denial.

Hyperactivation of T cells caused by COVID leads to their exhaustion and organ damage. With multiple exposures the depletion of T-Cells leads to weakened immune systems and premature death. It is an airborne auto-immune disease.

Hmmm... dont think it is like that. Where is evidence of actual decrease in immune cells like you see in AIDS? Haven't seen any.
But that doesnt mean COVID is a 'harmless' cold. It is a serious disease that does have some ill effects for some people. And that can include immune system issues. The problem with COVID is that it now entrenched with us, and even if only a small % get bad effects, the fact that people will have multiple reinfections means the number of us getting these bad effects will be large.

SARS-CoV-2 is like airborne HIV. And like HIV approx 10 years before it presents as full blown AIDS

@BrianNo way. The Yanks are gunna fold on the Ukies? Who will ever trust them again...

@Sergent SchultzFT: "The White House has issued a blunt warning that the US is set to run out of funds to aid Ukraine by the end of the year"

Well it seems the reason old Hawkey was a informant for the Yanks might have just popped out:
https://johnmenadue.com/asio-and-the-kgb-new-information-on-hawke-v-combe/

@Ken from KyevCooked!

"Ô Satan, prends pitié de ma longue misère!"

?si=LYKitVTyh3EVFdEd

@Padre Pio, Vatican CityI'd love a Glorious Pope. Is there one on a stick I can buy in the Vatican Square?
Especially would like one of the Polish Pope Carol. A stick square up his arse, and his cassock all covered in blood and cum.

Our glorious Pope is not without sin, like all of us. But too think he would be behind the slaying of the first President of the true faith is a blasphemous allegation!
You should get on your knees and pray a thousand rosary's for forgiveness you hillbilly swine. And once you done that you can get me a drink!

Thar Pope, he git jealous when he see 'ol Johnny fornicat'n with all them ripe tarmaters. So, he shot 'm. 'N blame it on a Commie 'n a Jew.

Now I was wondering why The Pope would want to knock off JFK. But then I remembered Jack was a Mick and all.
Maybe he reneged on the promise to make Catholicism the National Religion of the USA?
I am sure JFK had a 1000 enemies. Likely Il Papa was just another one in the line.

@RicardovitzThat I'd like to see

@Altered StatesWhat a Yank boot lickin tart she turned out to be.

Y'all is a bunch 'o dummies. He ain't dead. CIA wrapped 'ol Hank up in a sewer-side vest 'n snuck him in tar Gaza fer his last "dipautomatic" mission!!! GONA GO BOOOOOOOOOOOOOOOOOOOOOOOOOOOOOM!

Finally, 20 years later, Kissinger is going to get his arse reamed by Satan.

I be thar Preident, Prime Minister 'n King of me own domain. But, see I git smarty smarts. Smart more 'n all thar brains shot out of that dead Kennedy's brain. Tain't no one never even tried ta kill 'ol Ricky!!!

Smiling Jack. Thought they would make him President for life.
But he crossed the wrong people. These guys made him President, so he fucking owed them. Selling out their Havana gold mine was the last straw.
So Smiling Jack is smiling no more.

Looks like Squeaky Albo better change direction and get his head out of the Yankee arse if he wants to be more than a 1 term PM.
What a pathetic turd he is.

Just stay beside the pool Boxy. You know it will be nice and cool, especially if there are some Boxettes to eye off ;)

OooooooWeeeee!!! That li'll gal, now that thar be a look like she done saw Johnnie slide his lickered-up pecker way up inside Blondie's pussy. Now, I git thar real deal story 'bout how 'n why he got his head all blowed in. Jackie done hired a commie 'n a jew tar git that filthy fornicator dead!!!

Flam, I git sometin tar say ta you - YOU DERN'T KNOW NOTHIN!!! Tain't a lick 'o sense runn'n round that helll-fire smokin skull of yers. I'm a gonna tell ya what I know. That thar Jew Biden - he ain't gonna be president no more. Nosiree - he'
s doner 'n turkey-shine.

@RicardovitzOver the years Ricky your grammar and elocution has really dropped by the wayside.
Too much diddling your sister and some secret meth-huffiing on the side I reckon.

You call him Jack 'Israel' Ruby. Are you insinuating it was Mossad that killed Lee Harvey Oswald?
Outrageous anti-semitism!

@LordyLordyLordyMake that President Javier Milei!

Who is gunna pop the OrangeMan? Some hero from the nether regions of this globe. Fleeing injustice and terror, they will come to the US of A seeking hope and salvation. But there they will be mocked and ridiculed by President Trump and his followers. Finally he won't take it any more.
And then freedom will prevail!

I see it now. You are riffing on the John Lennon line about death being just like swapping cars. I can dig it man.
I tell you what, I wouldn't mind lifting the veil and hoping into the car with that blonde chick. It'll be very groovy.

The Whiteman's fear.
It rules this land.

Oh, way down here in thar land of cotton,
Old times tain't never forgotten
Look away! Look away! Look away! Dixie Land.
In Dixie Land where I was born in
Early on one frosty mornin'
Look away! Look away! Look away! Dixie Land.
Old Willy Cyrus was a weaver,
shot dead cuz he be a gay deceiver
Look away! Look away! Look away! Dixie Land.
n*g*e* Joe put his arm around her
blue gums stretched as fierce as a forty pounder
Look away! Look away! Look away! Dixie Land. Then Beth's husband caught sight of Joe, n*g*e*-dick 'bout on his beau, hacked 'm up with his meat cleaver, Look away! Look away! Look away, Dixie Land. https://external-content.duckduckgo.com/iu/?u=https%3A%2F%2Fi5.walmartimages.com%2Fasr%2F8287ef39-c786-4cb6-a4a2-cf2581950630_1.db8515d997076ef5b509677fbcc57a5b.jpeg&f=1&nofb=1&ipt=680f0cbd299741e2c2f5455a60d7fac8337568e6cf45b5e57a658612f879000a&ipo=images

Good ideas Mr Boxhead. Always on the money.
But best you keep out of the sun. Looking like a fried tomato there.

Killing thousands and in the end Hamas will be there and they will swap prisoners.
How fucking useless is the IOF.

Dear Lord. Save us from the idiocy of the Common Hillbilly Republican Voting Man.

Ahhh, Father, I git a Negress gal who will git ya right with the Lord. She gonna take ya out to me cabbage patch 'n work thar Devil out of ya. You gonna like it down here on Ricky's Plantation, Father. Yessiree, yer soul's gonna be saved. Now, I git a li'll hymn we's gonna sing:





"I say to that undertaker,
Undertaker please drive slow
Fer this worker you are carrying
Lord, I be sad ta see her go. She picked cotton, 'n cabbage, 'n greens all day 'n night. Cain't be no better home a-waiting
her, In the sky, Lord, in the sky."

Rinki-dink Chinky Xi Jinping feeling a bit left out, even after a San Fran visit.
Meanwhile Squeaky Albo's backside still sore and sticky after the reaming from his DC betters during his trip there.

US President's love affair with Putln:
https://x.com/unlimited_ls/status/1724536177946959910?s=20

Ah you heathen dog! I wouldnt give you the steam off my shit. You and your devil worshipping ways are heading straight to hell.
The only true way is the hallowed steps of St Peter and the Church of Rome that he built. Now get on your knees and repent.

And while your down there get me a drink you Protestant bum.

Come on down, Father. I'll git thar boys ta lite up a Cross on the Pray'n Mound fer ya. Dern't never ask 'em if they's Protestants. I reckon they git thar own way 'o pray'n, Father!!! https://external-content.duckduckgo.com/iu/?u=https%3A%2F%2Fs.abcnews.com%2Fimages%2FUS%2Fabc_kkk_dm_121026_wmain.jpg
&f=1&nofb=1&ipt=9d87eb5a6ab245fed16e13367362e7a2ba000d98644b3313bec9836bddb6192c&ipo=images

Oh hillbilly! Sounds like the Land the Lord has sent us. Tell me, are there any Protestants nearby? I would hope not, as I want my slice of Heaven to be glorified only to the Sacred Church of Rome.

Some folks call my piece 'o earth Zion. Cuz, I dern't give no nevermind 'bout if yer a n*g*e* or a jew. Long as y'all pick my maters, cotton, cabbage, 'n corn, I treat ya all thar same. Hog jowls 'n fatback fer ya in thar morn. A snort of shine 'n some meth in thar eve. Yessiree, I keep my workers happy happy happy!!!